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Running Happily

What is Zyprin?

Each capsule contains:

• 15mg of  L-methylfolate

• 250mg of DMAE.


Folate, when metabolized into its active form L-methylfolate, crosses the blood-brain barrier.  It is thought to help boost the production of the natural chemicals in the brain responsible for mood.  These natural chemicals (neurotransmitters) that affect mood include dopamine, serotonin, and norepinephrine.


DMAE is a chemical that is involved in a series of reactions that form acetylcholine, a chemical that is found in the brain and other areas of the body. Acetylcholine is a “neurotransmitter” that helps nerve cells communicate.

L-Methylfolate Study

Methylfolate, a bioavailable form of folate that plays a role in neurotransmitter synthesis, can improve a person’s response to antidepressant medications. In fact, several studies have documented the enhanced efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) when taken with L-methyfolate.

In a 2012 study published in the American Journal of Psychiatry, researchers conducted two randomized, double-blind, parallel sequential trials to evaluate the effect of L-methylfolate augmentation in the treatment of major depressive disorder in patients who had a partial response or no response to selective serotonin reuptake inhibitors (SSRIs). Adjunctive L-methylfolate at 15 mg/day showed significant improvement in response rate and degree of change in depression scores as compared to continued SSRI therapy plus placebo.

My Approach
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